Trace Metal Analysis

Trace Metal Analysis by AAS & ICP-MS

Trace metal analysis is an analytical technique employed to determine the presence of trace metals and quantify them in chemical and pharmaceutical samples, drug formulations and food samples. It plays a significant role in the formulation and development of drugs, chemicals, cosmetics, medical devices, etc. by determining, identifying and quantifying the trace metals in a sample.

While they are present only in scant levels, trace metals can still act as potential deterrents in drug efficacy, for example. Thus, to prevent product risks, and understand the nature and quantity of trace metals, analysis is essential. Additionally, determination of trace metals can result in process improvement and enhanced product quality and efficacy.

Most importantly, any harmful side effects from these trace metals can be identified, which is especially critical in oral and topical use of food products or formulations. The interaction of the trace metals with other metals or chemicals in the compound could act in reverse or result in dangerous effects. Trace metal analysis makes manufacturers aware of the potential danger and protects end users.

ICP-MS instrument used for trace metal analysis

Technology and expertise

We conduct trace metal analysis in our technologically upgraded metal testing labs for superior results. Trace metal analysis is performed using ICP-MS of Agilent Technology with the latest MassHunter software. Elemental impurities are analysed as per USP and ICH Q3D. Since these metals are present at trace levels, the sensitivity of the technology and equipment used is key for high accuracy results.

Our team of experts stay abreast of current global regulatory standards for permissible limits of trace metals, which are frequently changing. Their analytical and regulatory knowledge coupled with the latest, versatile technology in our metal testing labs lets us provide accurate results.

Based on client needs, chemical and metal testing is done to ppm, ppb, and ppt levels, to ensure accuracy and reliability. We also undertake method development and validation projects by ICP-MS.

Analyst preparing samples for ICP-MS

Elemental impurities

Our chemical testing labs are equipped to test for the presence of the following metals.

Class I

  • Arsenic
  • Lead
  • Mercury
  • Cadmium

Class II A

  • Cobalt
  • Vanadium
  • Nickel

Class II B

  • Selenium
  • Silver
  • Thallium
  • Gold
  • Palladium
  • Iridium
  • Osmium
  • Rhodium
  • Ruthenium
  • Platinum

Class III

  • Barium
  • Chromium
  • Copper
  • Tin
  • Nickel

Class IV

  • Aluminium
  • Boron
  • Iron
  • Zinc
  • Potassium
  • Calcium
  • Sodium
  • Manganese
  • Magnesium
  • Tungsten

Analysis by AAS

We have an AAS from Perkin Elmer with Flame and MHS technique. The following tests are performed on AAS for chemical and metal testing in our metal testing labs:

  1. Identification by AAS

  2. Assay by AAS

  3. Mineral Analysis

  4. Method Development and Validation

FAQ's

ICP-MS (Agilent Technology, with the latest MassHunter software) and AAS (Perkin Elmer, with flame and MHS techniques).

Elemental impurities are analysed as per USP and ICH Q3D.

Based on your requirement, testing is done to ppm, ppb and ppt levels.

Class I (arsenic, lead, mercury, cadmium), Class II A and II B, Class III and Class IV elements, including metals such as nickel, cobalt, palladium, platinum, copper, iron, zinc and aluminium.

Yes. We undertake method development and validation projects by ICP-MS, and on AAS as well.

Send an enquiry first. Once feasibility is confirmed and you have our quotation, deliver samples to our laboratory in Wagle Estate, Thane, or ask us to arrange collection.

Yes. Each sample receives a Certificate of Analysis, released only after the report and raw data are verified by the Section Head and QA.

Share your sample details and requirements through our enquiry form. We send quotations by email.

Need accurate, compliant testing for your products?

Share your sample details and requirements. We’ll confirm feasibility, recommend the right analytical approach and send you a quotation.

Request a quote